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Habba Syndrome|habba syndrome symptoms| lupis, lupus eritematoso sistemico

WHAT IS HABBA SYNDROME

It is an association between a dysfunctional, intact gallbladder and chronic diarrhea. Patients with the syndrome present with varying degrees of chronic diarrhea (three or more bowel movements per day for at least three months). Diarrhea is classically described as frequent, loose bowel movements and may be watery in nature. They could be explosive at times and may even be associated with great urgency and even incontinence. Diarrhea is mostly after meals (post prandial diarrhea). Because of this urgency, patients usually look for a bathroom wherever they go, also known as “bathroom mapping”.

These symptoms are usually very distressing and may cause social embarrassment and interference with daily activities. Some patients are even homebound in fear of social embarrassment. Some lose weight because they are afraid to eat for fear of getting diarrhea.

Diarrhea is rarely nocturnal, unless the patient had a late meal close to bedtime.
have any pain associated with this syndrome?

The patient would not necessarily have abdominal pain related to the gallbladder disease. They could be completely free of any abdominal pain. The gallbladder function is only determined by an abnormal radio-nuclear test that studies the function of the gallbladder (DISIDA scan with CCK injection). This test is non-invasive and can be performed in all well-equipped hospitals and radiology centers.

SYMPTOMS AND TREATMENTS:

What are the cardinal symptoms of this syndrome?

1. Post-prandial diarrhea (varying from simple urgency to incontinence) and fear of eating to avoid diarrhea
2. Dysfunctional gallbladder as determined by radiological testing
3. Failure to respond to standard therapy of IBS or spastic colon
4. Favorable response to bile acid binding agents

What should be done if you have these symptoms?

Check with your primary doctor or gastroenterologist.

A basic work up of the symptoms needs to be done such as stool analysis, lab work, x-rays, and colonoscopy. Further testing to rule out malabsorptive conditions, inflammatory bowel disease (ulcerative colitis and Crohn’s disease), and cancer need to be done before syndrome diagnosis can be confirmed.

These tests must be done to rule out other treatable conditions before starting therapy for the Habba Syndrome.

What is the treatment for this syndrome?

Since the basic pathology of the syndrome is inappropriate bile in the gastrointestinal tract related to a dysfunctional gallbladder, therapy should be aimed at changing the constitution of bile acids to decrease the diarrheal effect of these bile acids.

Agents that bind bile acids have been tried for many years and have been proven to be safe, effective, and inexpensive. Some are available in generic forms.

These agents should be used ½ hour prior to meals to bind the bile acids and to become effective. In the original publication of the syndrome, cholestyramine was used with excellent response.

How soon should I expect improvement?

Symptoms should improve within a few days of continuous therapy. One may have to stay on these medications for a long time. Dosage can be increased or tapered as symptoms stabilize.

Is removing a gallbladder surgically an accepted mode of therapy?

Cholecystectomy (removal of the gallbladder) should not influence the outcome of the symptoms. In fact, approximately 10% of patients have similar symptoms after gallbladder removal. Hence, surgical removal of the gallbladder for the reason of chronic diarrhea is not indicated.

How many people suffer from this syndrome?

Most likely millions or people that are diagnosed with either IBS or spastic colon have the Habba Syndrome. It is estimated that approximately 20 million Americans suffer from IBS or similar conditions.